GRK2: A new target for inhibiting macrophage infiltration and angiogenesis in...
This new article publication from Acta Pharmaceutica Sinica B, discusses how GRK2 inhibits Flt-1+ macrophage infiltration and its proangiogenic properties in rheumatoid arthritis.
View ArticleStudy shows Omicron variants evade immune system like predecessors,...
Researchers compared SARS-CoV-2 Omicron variant of concern replication in human cell lines and primary airway cultures and measured host responses to infection.
View ArticleLung cancer prediction using biomarkers based on bronchoalveolar fluid...
The lung microbiomes of patients with benign and malignant pulmonary diseases.
View ArticleResearchers discover non-opioid therapeutic for relieving neuropathic pain
Among the most difficult types of pain to alleviate is neuropathic pain, pain that is usually caused by damage to nerves in various body tissues, including skin, muscle and joints.
View ArticleIs there an association between vitamin D, immunocompetence, and aging?
The role of an individual’s immunocompetence in the responsiveness to vitamin D.
View ArticleCRISPR revolutionized: New method edits genes directly in the body
Most approved gene therapies today, including those involving CRISPR-Cas9, work their magic on cells removed from the body, after which the edited cells are returned to the patient.
View ArticleStudy sheds light on 7-DHC's potential to induce cell death-resistant state...
Cell death is fundamental to life and, thus, healthy aging. In the realm of cellular biology, ferroptosis (a form of programmed cell death) has emerged not only as a focal point of research for its...
View ArticleNew approach to treating neuropathic pain offers the possibility of...
Researchers investigated the selective activity of sigmoid 2 receptor (σ2R) or transmembrane protein 97 (TMEM97) ligands on murine neuropathic pain models, their effects on nociceptive neurons and the...
View ArticleSARS-CoV-2 fragments found to mimic immune system peptides, fueling inflammation
Study reveals SARS-CoV-2 fragments mimic immune peptides, potentially driving the virus's inflammatory response, offering insights into COVID-19's severe inflammation mechanisms.
View ArticleNever-before-documented genetic disorder causes rare lung disease
The macrophage is one of the body's most important inhabitants. Meaning "big eater" in Greek, this immune cell consumes and digests problematic elements from microbes and cancer cells to dust and debris.
View ArticleStudy finds interleukin-24 enhances CAR-T cell therapy's effectiveness...
The effect of Interleukin-24 (IL-24) on CSCs and CAR-T cell therapy.
View ArticleSmoking, infection, and BMI found to significantly sway immune response,...
Study reveals how smoking, CMV latent infection, and BMI significantly influence cytokine release, impacting immune response variability and potentially affecting disease risk.
View ArticleCombo of targeted and immunotherapy may boost NSCLC treatment by overcoming...
Researchers evaluated rational combination treatment regimens for advanced/metastatic non-small-cell lung cancer (NSCLC).
View ArticleResearchers discover new mechanism of action between the nutrient adaptation...
Researchers used an organ-wide approach to quantitatively analyze cell number, size, and identity regulation upon nutrient-induced tissue adaptation of the Drosophila midgut.
View ArticleNovel splicing mechanism for short introns discovered
Researchers confirm that the established pre-mRNA splicing mechanism that appears in textbooks cannot work in a subset of human short introns: A novel SAP30BP–RBM17 complex-dependent splicing has been...
View ArticleComprehensive analysis of immune checkpoint inhibitors reveals endocrine...
Announcing a new publication for Acta Materia Medica journal. Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment but pose a challenge of immune-related adverse events (irAEs),...
View ArticleRevolutionary tool for tracking physical interactions between different cells
One of the fundamental goals of basic biology is understanding how diverse cell types work in concert to form tissues, organs, and organ systems.
View ArticleGut bacteria strains could be the key to predicting cancer treatment success
Researchers discovered that gut microbiota strains can predict the effectiveness and adverse effects of immune checkpoint blockade (ICB) therapy in rare cancer patients.
View ArticleLAG-3 protein structure may be the key to unlocking new cancer treatments
A molecular “snapshot” of a protein can be critical to understanding its function. Scientists at Stanford and NYU have published and investigated a new structure of the protein LAG-3 which could enable...
View ArticleResearchers discover diverse and spatially coordinated cardiac cells involved...
Researchers use a combination of scRNA-seq and multiplexed error-robust fluorescence in situ hybridization to better understand cardiac cell types.
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